2 cells of the infiltrate in irritant and allergic positive patch test reactions immunophenotypic studies
The Role of the Media in Promoting and Reducing Tobacco Use doc
Ngày tải lên :
06/03/2014, 01:20
... explain the paradox of millions who successfully The influence of the media and their role in product marketing represent one of the key developments of modern society Effective advertising and ... discounting, and brand marketing, in the context of the current regulatory and social environment Consumer marketing Consumer-product marketing efforts, including pricing, distribution, packaging, and ... that include several aspects of tobacco advertising and promotion, the use of media by the tobacco industry for corporate Monograph 19 The Role of the Media sponsorship and advertising, the influence...
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nanotechnology in medical applications state of the art in materials and devices
Ngày tải lên :
28/05/2014, 14:35
... basic understanding of the origin of the unique properties of nanomaterials Therefore this report starts with a short section explaining the definitions and features of nanoscience and nanotechnology, ... nanotechnology in medical applications The review was performed on the request of the Department of Pharmaceutical Affairs and Medical Technology of the Ministry of Health, Welfare and Sports in the Netherlands ... studies of animal models of disease and is beginning to be used in clinical investigations as a non-invasive means of monitoring disease progress and response to therapeutics Molecular imaging agents...
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Review Cells of the synovium in rheumatoid arthritis pot
Ngày tải lên :
09/08/2014, 10:20
... and act reciprocally on T cells to drive production of other cytokines and surface molecules involved in the effector phase of joint inflammation The population of effector T cells in the joint ... understanding of the role of T cells in arthritis is the IL-1Ra-deficient mouse strain [24] IL-1Ra is an endogenous, natural inhibitor of IL-1 bioactivity through binding and blockade of the IL-1 ... Substitution of tryptophan for arginine at residue 620 results in a gain -of- function, leading to decreased TCR signaling and decreased production of interleukin (IL)-2 [11] The current understanding is...
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Review Cells of the synovium in rheumatoid arthritis docx
Ngày tải lên :
09/08/2014, 10:20
... Although the molecular mechanism of degradation of the surface cartilage of the inflamed joint is not fully understood, a combination of the invasive properties of the synovial tissue and the expression ... weak point in the joint, which allows osteoclasts to invade properly and to undermine the surface cartilage These tunnels are then filled by inflammatory tissue, the pannus, which allows the inflammatory ... signs and symptoms of RA and they also show effects on joint structure The latter effect may either be an indirect one through lowering joint inflammation or is based on a direct inhibition of the...
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Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" ppsx
Ngày tải lên :
09/08/2014, 10:20
... important in the pathogenesis of a murine model of arthritis Specifically, the involvement of B cells in priming T cells was dissected within the context of proteoglycan (PG)-induced arthritis by using ... [12] Their engagement results in rapid activation of the innate and adaptive immune systems to effect clearance of pathogens There is mounting evidence suggesting involvement of TLR signalling in ... proliferation-inducing ligand; BAFF, B cell-activating factor of the TNF family; CXCL, CXC chemokine ligand; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor ligand (TLR)9 These immune...
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Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" pot
Ngày tải lên :
09/08/2014, 10:20
... DC in RA, and in the murine collagen-induced arthritis model Dendritic cell antigen presentation in induction and maintenance of RA DC play an essential role in the priming of lymphocytes in ... cytokines produced Produce proinflammatory and anti-inflammatory cytokines and chemokines in response to a variety of signals Tissue location Epithelium and epithelial draining lymph nodes Nonepithelial ... abundant in the synovial lining and sublining layers of the synovium associated with CCL20 (MIP-3α)-expressing cells, as well as in rheumatoid nodules and the synovial fluid In synovial tissue the...
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Báo cáo y học: "Review Cells of the synovium in rheumatoid arthritis" pot
Ngày tải lên :
09/08/2014, 10:21
... investigations in vitro and in vivo have resulted in new findings about the role of the chondrocyte in remodeling the cartilage matrix in the RA joint Although the mediators involved in immunomodulation and ... expression of β-catenin in joint tissues of patients with RA, but high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes and synovial ... for binding the circulating leukocytes and other cell types with which they interact in the inflamed tissue, including macrophages, dendritic cells, and fibroblasts The principal families of adhesion...
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Báo cáo y học: "Review Cells of the synovium in rheumatoid arthritis" ppsx
Ngày tải lên :
09/08/2014, 10:22
... Fibroblast-macrophage interaction Because of the prominent numbers of Mφ and fibroblasts and their activated status in RA synovial tissue, the interaction of these cells is critical for the resulting inflammation ... of integrin/selectin pairs on the surface of the two cell types (reviewed in [2]) Because the synovial cytokine milieu (including the Mφ-derived TNF-α) upregulates the expression of these ligand ... molecules and TGF-β receptors in the lining and sublining layers, at the cartilage-pannus junction, and in the synovial fluid [78-80] The pro-inflammatory effects of TGF-β are substantiated by induction...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... capable of binding to the cytoplasmic domain of the siglec-10 protein The binding of SHP-1, however, was missing from the Y667F mutant indicating this to be the preferred tyrosine for interaction ... binding of any of the adherent cell types Binding assays with siglec-expressing COS7 cells Results for COS7 binding experiments are shown in Fig 5C There was a significant increase in binding of ... binding, however, was only diminished by < 50% in the Y667F mutant, indicating that SHP-2 may be binding both to the tyrosine at position 667 and to other tyrosines in the cytoplasmic tail of...
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The Rise and Fall of Abacus Banking in Japan and China phần 2 docx
Ngày tải lên :
06/08/2014, 20:22
... governance of the banking institutions of the two countries, freeing bank managers from the control of regulators, and educating them about the principles and the mentality of risk management, in turn, ... risks and rewards of their investments Arguing these contentions in more detail, the remainder of this book contains two parts Part I discusses the rise and fall of abacus banking in Japan in the ... Japan in the postwar period and the banking crisis of the 1990s, and Part II addresses the rise and fall of abacus banking in China and the looming banking crisis of the 1990s A chapter-by-chapter...
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Báo cáo y học: "Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2" potx
Ngày tải lên :
09/08/2014, 10:23
... predominantly the tunica intima consisting of the endothelial layer and the basement membrane, and αSMA (e, f) staining predominantly the tunica media consisting of the muscular layer of the arteriole ... staining in the infrapatellar fat pad (IPFP) tissue vasculature 3G5 (a, b) staining predominantly the tunica adventitia consisting of supporting tissue in the vasculature, vWF (c, d) staining ... expanded in the presence of FGF-2 Although cell aggregates derived from cells expanded in the presence of FGF-2 stained for collagen type I, the immunostaining was increased at the peripheries and...
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Báo cáo y học: " Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China" ppt
Ngày tải lên :
11/08/2014, 21:21
... rE2 proteins For each of the variant C-strain rE2 proteins, the binding efficiency was determined by normalizing to anti-his-tag binding first, and then to the wt C-strain rE2 protein binding to ... For each of the rE2-AD proteins, the binding efficiency was determined by normalizing to anti-His-tag binding first, and then to C-strain protein or strain QZ-07 rE2-AD protein binding for anti-C-strain ... suggesting its essential role in maintaining the integrity of antigenic structure of E2 protein In addition, the substitutions of N777S, S779A, and T780I in this region enhanced binding of variant...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
Ngày tải lên :
13/08/2014, 05:21
... concentrated in the C2 region The four N-glycosylation sites in C2 and the site in the beginning of V3 were highly conserved in all patients throughout infection which is strongly indicative of convergent ... important role in the folding of the glycoproteins, in infection and in evasion from the host immune response (reviewed in [69]) We found that, as for HIV-1 [51,58], the majority of potential N-glycosylation ... References Competing interests The authors declare that they have no competing interests Authors' contributions NT designed and coordinated the study PB performed most of the cloning and sequencing experiments...
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Role of the survival proteins hsp27 and survivin in a small molecule sensitization to TRAIL mediated apoptosis 2
Ngày tải lên :
11/09/2015, 10:15
... independently of the presence of LY30, both resulted in a marked increase in cell death as reported in several studies Inhibition of the proteasome lead to an expected increase in survivin protein level in ... fractionation and analysis of cyt c and Smac release into the cytosol by Western blotting The purity of the cytosolic and mitochondrial fraction was confirmed by monitoring the absence of VDAC and CuZnSOD ... mitochondria against the ratio of the highest mitochondrial staining intensity to the total mitochondrial staining (A) Corresponding histogram of the mitochondrial aggregation (B) n=2 90 LY30 and TRAIL...
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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells
Ngày tải lên :
30/09/2015, 06:36
... affecting the function of kidney, manifested initially as a persistent elevation in urinary excretion of albumin and subsequently as an increase in excretion of protein, is often associated with the increased ... that in non-diabetic women (Malins, 1978) In spite of improvement in the management of diabetic pregnancies in the past decades, congenital malformations including NTDs in infants of diabetic mothers ... bending of the neural plate involves the formation of hinge regions The cells at the midline of the neural plate are called the medial hinge point (MHP) cells which are connected with the notochord...
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ROLE OF THE ERP29 IN MIGRATION, APOPTOSIS AND PROLIFERATION IN BONE MARROW STEM CELLS
Ngày tải lên :
02/10/2015, 17:15
... ADF/cofilin, are also act as regulators in mediating actin polymerization by controling the availability of activated actin monomers, debranching and depolymerizing proteins and capping and severing ... other cells by interacting with actin filaments in migrating cells Integrins can also act as signal transducer in the “inside-out signaling” model The activation of integrins is caused by talin ... attaches to the side of existing actin filaments and induces growth of a new branch of actin filament at a unique 70 degree angle from the preexisting actin filament Proteins, such as profiling and ADF/cofilin,...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
Ngày tải lên :
31/10/2012, 15:28
... and activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray results ... increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced liver damage Thus, the direct injection of low concentration of ethanol for the...
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Báo cáo y học: "Multivariate explanatory model for sporadic carcinoma of the colon in Dukes’ stages I and IIa"
Ngày tải lên :
03/11/2012, 11:34
... changes in the mevalonate pathway in patients with SCRC depending on the location of the tumour in the large intestine [31] 48 The use of LR for the observational studies continues to being authenticated ... by the different collaborators The fruit of that qualitative examination was the rejection of a total of controls and cases at the defining moment of the construction of the data package The ... pertaining to this new sampling were gathered in a retrospective manner from the archives of the Virgin Macarena and Virgin del Rocío Hospitals of Seville, the General Hospital of Mérida and also...
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How to translate some of the metaphors in Harry potter Books (book 3 and book 7) into Vietnamese
Ngày tải lên :
26/11/2012, 09:53
... All in all, translation in some certain meaning in a work of creativity and imagination Knowing the way is far different from actually going on that way In other words, theory and academic studies ... could therefore easily understand the sense, the meaning of the hidden comparison The reservation of metaphoric imagery contributes to create the beauty, imagination of the language, and is more of ... metaphors in the two books Harry Potter and the Prisoner of Azkaban and Harry Potter and the Deathly Hallows (by J.K Rowling) III.1 Reasons for choosing Harry Potter and the Prisoner of Azkaban and...
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